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25-Hydroxyvitamin D3 1-alpha-Hydroxylase :

25-Hydroxyvitamin D3 1-alpha-hydroxylase

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cytochrome P450, family 27, subfamily B, polypeptide 1
Identifiers
Symbol CYP27B1
Alt. Symbols VDD1, PDDR
Entrez 1594
HUGO 2606
OMIM 609506
RefSeq NM_000785
UniProt O15528
Other data
Locus Chr. 12 q13.3-q14

25-Hydroxyvitamin D3 1-alpha-hydroxylase is a cytochrome P450 enzyme in the proximal tubule which converts calcidiol to calcitriol (the bioactive form of Vitamin D).

Calcidiol

Calcitriol

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v • d • e
Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1
A1, A2, B1
CYP2
A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3
CYP4
A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20
CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51
CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)
v • d • e
Metabolism of vitamins, coenzymes, and cofactors
Vitamin A
Thiamine (B1)
Niacin (B3)
Folic acid (B9)
Vitamin C
Vitamin D
25-Hydroxyvitamin D3 1-alpha-hydroxylase - CYP27A1
Vitamin K

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