AM-905

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AM-905
Systematic (IUPAC) name
(6aR,9R,10aR)-3-[(E)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Identifiers
CAS number	?
ATC code	?
PubChem	9998522
Chemical data
Formula	C₂₃H₃₄O₃
Mol. mass	358.513 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

AM-905 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and reasonably selective agonist for the CB₁ cannabinoid receptor, with a Ki of 1.2nM at CB₁ vs 5.3nM at CB₂.^[1]

This article about a cannabinoid is a stub. You can help Wikipedia by expanding it.

[edit] References

^ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219

v • d • e

Cannabinoids

Plant cannabinoids

CBD • CBDV • CBN • CBG • CBV • CBL • THC • THC-C4 • THCV

Cannabinoid metabolites

11-Hydroxy-THC • 11-nor-9-Carboxy-THC

Endogenous cannabinoids

Arachidonoyl ethanolamide (Anandamide or AEA) • 2-Arachidonoylglycerol (2-AG) • 2-Arachidonyl glyceryl ether (noladin ether) • Virodhamine • N-Arachidonoyl dopamine (NADA) • Oleamide

Synthetic
cannabinoid agonists

Classical cannabinoids (Dibenzopyrans)	A-41988 • Ajulemic acid • AM-087 • AM-411 • AM-855 • AM-905 • AM-906 • AM-919 • AM-938 • AM-4030 • AMG-1 • AMG-3 • AMG-36 • AMG-41 • Dexanabinol (HU-211) • DMHP • Dronabinol • HU-210 • JWH-051 • JWH-133 • JWH-139 • L-759,633 • L-759,656 • Levonantradol • Nabilone • Nabitan • O-806 • O-823 • O-1057 • O-1125 • O-1238 • O-2545 • O-2694 • Parahexyl • THC-O-acetate • THC-O-phosphate

Nonclassical cannabinoids	CP 47,497 • CP 55,244 • CP 55,940 • HU-308 • Nonabine • 2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene

Aminoalkylindoles	AM-630 • AM-1241 • JWH-007 • JWH-015 • JWH-018 • JWH-073 • JWH-081 • JWH-122 • JWH-200 • JWH-210 • L-768,242 • Pravadoline • WIN 55,212-2

Aminoalkylpyrroles	JWH-030 • JWH-147 • JWH-307

Eicosanoids	AM-883 • Arachidonyl-2'-chloroethylamide • Arachidonylcyclopropylamide • Methanandamide • O-585 • O-689 • O-1812 • O-1860 • O-1861

Others	BAY 38-7271 • BAY 59-3074 • GW-405,833 • GW-842,166X • JWH-171 • O-2220 • Org 28611

Endocannabinoid
activity enhancers

AM-404 • CAY-10401 • CAY-10402 • N-arachidonoyl-serotonin • O-1624 • PF-622 • PF-750 • URB-597 • URB-602 • URB-754• JZL184

Cannabinoid antagonists
and inverse agonists

AM-251 • AM-281 • AM-630 • BML-190 • CAY-10508 • CB-25 • CB-52 • Drinabant • Ibipinabant • JTE-907 • LY-320,135 • MK-9470 • NESS-0327 • O-1184 • O-1248 • O-2050 • O-2654 • Org 27569 • Otenabant • Rimonabant • SR-144,528 • Surinabant • Taranabant • VCHSR

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