Phosphatidylinositol (3,5)-bisphosphate

From Wikipedia, the free encyclopedia

Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,5)-bisphosphate

Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P₂) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5)P₂ in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking.

PtdIns(3,5)P₂ is dephophosphorylated by members of the myotubularin lipid phosphatase family on the 3 position of the inositol ring generating Phosphatidylinositol 5-phosphate (PtdIns5P).

The phosphoinositide-binding domain in a number of proteins binds to PtdIns(3,5)P₂, including the PH domain in centaurin-β2, the PX domain of SNX1, and a novel domain in Atg18p.

[edit] References

• Michell RH, Heath VL, Lemmon MA, Dove SK. (2006) Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends Biochem Sci. 31(1):52-63. [1]

[edit] External links

• MeSH phosphatidylinositol+3,5-bisphosphate

This cell biology article is a stub. You can help Wikipedia by expanding it.

Phosphatidylinositol (3,5)-bisphosphate - Related Items

• Phosphatidylinositol (3,5)-bisphosphate

Phosphatidylinositol (3,5)-bisphosphate - In the news

• Picunche
• CAPS (Computer Animation Production System)
• Kaseda, Kagoshima
• Emmett Till
• United States House of Representatives elections in California, 1918
• Credit - Phosphatidylinositol (3,5)-bisphosphate
• Tf1
• Wii
• Picunche
• ESP Guitars
• Western Desert Campaign
• MC68000
• Yongkang, Zhejiang
• Bank - Phosphatidylinositol (3,5)-bisphosphate
• Lingerie
• Real Estate
• SEO
• Ipod
• Mobil phone
• Picunche
• Block grant
• Nur Mahana
• Toyota Sprinter
• Richard W. Thompson
• Trading
• Travel
• Phosphatidylinositol (3,5)-bisphosphate