| Phosphatidylinositol 3-phosphate | |
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| Other names | sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate |
| Molecular formula | C11H20O16P2 |
| Molar mass | 470.214 |
| PubChem | |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol.
PtdIns3P is dephophosphorylated by the myotubularin family of phosphatases, on the D3 position of the inositol ring.
Both FYVE domains and PX domains – found in proteins such as SNX1, Hrs, and EEA1 – bind to PtdIns3P.
The majority of PtdIns3P appears to be constitutively synthesised by the class III PI 3-kinase, Vps34, at endocytic membranes. Class II PI 3-kinases also appear to synthesise PtdIns3P, their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3P may be synthesised upon cell stimulation.
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