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URB754

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URB754
IUPAC name 6-methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
Identifiers
CAS number 86672-58-4
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references

URB754 was originally reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase.[1] However, recent studies have shown that URB754 failed to inhibit recombinant MGL, and brain FAAH activity was also resistant to URB754.[2] Some controversy in the field remains regarding the use of this compound.

[edit] References

  1. ^ Makara JK, Mor M, Fegley D, Szabó SI, Kathuria S, Astarita G, Duranti A, Tontini A, Tarzia G, Rivara S, Freund TF, Piomelli D (2005). "Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus". Nat. Neurosci. 8 (9): 1139–41. doi:10.1038/nn1521. PMID 16116451. 
  2. ^ Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT (2006). "URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain". Chem. Biol. 13 (8): 811–4. doi:10.1016/j.chembiol.2006.07.008. PMID 16931330. 


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Cannabinoids
Plant cannabinoids
CBD • CBDV • CBN • CBG • CBV • CBL • THC • THC-C4 • THCV
Cannabinoid metabolites
Endogenous cannabinoids
Arachidonoyl ethanolamide (Anandamide or AEA) • 2-Arachidonoylglycerol (2-AG) • 2-Arachidonyl glyceryl ether (noladin ether) • Virodhamine • N-Arachidonoyl dopamine (NADA) • Oleamide
Synthetic
cannabinoid agonists
Classical cannabinoids
(Dibenzopyrans)

A-40174 • A-41988 • Ajulemic acid • AM-087 • AM-411 • AM-855 • AM-905 • AM-906 • AM-919 • AM-938 • AM-4030 • AMG-1 • AMG-3 • AMG-36 • AMG-41 • Dexanabinol (HU-211) • DMHP • Dronabinol • HU-210 • JWH-051 • JWH-133 • JWH-139 • JWH-229 • JWH-359 • L-759,633 • L-759,656 • Levonantradol • Nabilone • Nabitan • O-806 • O-823 • O-1057 • O-1125 • O-1238 • O-2545 • O-2694 • Parahexyl • THC-O-acetate • THC-O-phosphate
Nonclassical cannabinoids
Aminoalkylindoles

AM-630 • AM-1241 • JWH-007 • JWH-015 • JWH-018 • JWH-073 • JWH-081 • JWH-122 • JWH-200 • JWH-203 • JWH-210 • JWH-249 • JWH-250 • L-768,242 • Pravadoline • WIN 55,212-2
Aminoalkylpyrroles

JWH-030 • JWH-147 • JWH-307
Eicosanoids
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Endocannabinoid
activity enhancers

AM-404 • CAY-10401 • CAY-10402 • JZL184 • N-arachidonoyl-serotonin • O-1624 • PF-622 • PF-750 • URB-597 • URB-602 • URB-754
Cannabinoid antagonists
and inverse agonists

AM-251 • AM-281 • AM-630 • BML-190 • CAY-10508 • CB-25 • CB-52 • Drinabant • Ibipinabant • JTE-907 • LY-320,135 • MK-9470 • NESS-0327 • O-1184 • O-1248 • O-2050 • O-2654 • Org 27569 • Otenabant • Rimonabant • SR-144,528 • Surinabant • Taranabant • VCHSR
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